9月
Nutlin-C1-amido-PEG4-C2-N3；化合物 T17902E3 ligase Ligand-Linker Conjugates 48|||MDM2 Ligand-Linker Conj (2024/9/1)
簡(jiǎn)介：nutlin-c1-amido-peg4-c2-n3 is a novel compound that functions as a ligand-linker conjugate for the e3 ligase. it is a synthesized molecule incorporating the mdm2 ligand derived from nutlin 3, and a 4-unit peg linker. this compound is specifically designed for utilization in protac technology.
cIAP1 Ligand-Linker Conjugates 10；化合物 T17901E3 ligase Ligand-Linker Conjugates 47；E3 ligase Ligand-L (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 10 comprise of an iap ligand and a protac linker, which facilitates the design of snipers. these conjugates incorporate an iap ligand that interacts with the e3 ubiquitin ligase, and a protac linker. snipers can be developed using ciap1 ligand-linker conjugates 10.
cIAP1 Ligand-Linker Conjugates 8；化合物 T17900E3 ligase Ligand-Linker Conjugates 46；E3 ligase Ligand-Li (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 8 comprises an iap ligand for the e3 ubiquitin ligase and a protac linker. this compound is specifically utilized for the purpose of sniper design[1].
Fosaprepitant dimeglumine；福沙吡坦二甲葡胺L785298|||MK-0517|||Fosaprepitant dimeglumine salt；福沙匹坦二甲葡胺|||L785 (2024/9/1)
簡(jiǎn)介：fosaprepitant dimeglumine (mk-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, n-phosphorylated prodrug of aprepitant, with antiemetic activity. upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance p/neurokinin 1 (nk1) receptors in the central nervous system (cns). this inhibits receptor binding of the endogenous substance p and prevents substance p-induced emesis.
cIAP1 Ligand-Linker Conjugates 9；化合物 T17899E3 ligase Ligand-Linker Conjugates 45；E3 ligase Ligand-Li (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 9 feature an iap ligand specifically targeting the e3 ubiquitin ligase, along with a protac linker. it is valuable tools for developing snipers[1].
cIAP1 Ligand-Linker Conjugates 7；化合物 T17898E3 ligase Ligand-Linker Conjugates 44；E3 ligase Ligand-Li (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 7 is a chemical compound that combines an iap ligand for the e3 ubiquitin ligase with a protac linker. it is utilized in the design of snipers[1].
cIAP1 Ligand-Linker Conjugates 13；化合物 T17897E3 ligase Ligand-Linker Conjugates 43；E3 ligase Ligand-L (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 13, containing an iap ligand for the e3 ubiquitin ligase, and a protac linker, are utilized in the development of snipers[1].
cIAP1 Ligand-Linker Conjugates 4；化合物 T17896E3 ligase Ligand-Linker Conjugates 42；E3 ligase Ligand-Li (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 4 is a chemical compound that comprises an iap ligand specifically designed for the e3 ubiquitin ligase and a protac linker. this compound, ciap1 ligand-linker conjugates 4, has the potential to be utilized in the development of snipers[1].
cIAP1 Ligand-Linker Conjugates 1；化合物 T17895E3 ligase Ligand-Linker Conjugates 41；E3 ligase Ligand-Li (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 1 is composed of an iap ligand for the e3 ubiquitin ligase and a protac linker. this compound, ciap1 ligand-linker conjugates 1, is particularly useful in the development of snipers[1].
cIAP1 Ligand-Linker Conjugates 3；化合物 T17894E3 ligase Ligand-Linker Conjugates 40；E3 ligase Ligand-Li (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 3 are chemical compounds comprising an iap ligand designed specifically for the e3 ubiquitin ligase and a protac linker. these conjugates, denoted as ciap1 ligand-linker conjugates 3, find utility in the design of snipers, short for specific and non-genetic iap-dependent protein erasers [1].
cIAP1 Ligand-Linker Conjugates 5；化合物 T17893E3 ligase Ligand-Linker Conjugates 39；E3 ligase Ligand-Li (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 5 is a chemical compound consisting of an iap ligand that targets the e3 ubiquitin ligase, and a protac linker. this compound, ciap1 ligand-linker conjugates 5, is specifically designed for the development of snipers[1].
cIAP1 Ligand-Linker Conjugates 12；化合物 T17892E3 ligase Ligand-Linker Conjugates 38；E3 ligase Ligand-L (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 12 is a chemical compound that combines an iap ligand, which targets the e3 ubiquitin ligase, with a protac linker. this compound, ciap1 ligand-linker conjugates 12, is valuable for creating snipers[1].
cIAP1 Ligand-Linker Conjugates 2；化合物 T17891E3 ligase Ligand-Linker Conjugates 37；E3 ligase Ligand-Li (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 2 is a chemical compound that combines an iap ligand for the e3 ubiquitin ligase with a protac linker. this compound is particularly useful in the design of snipers [1].
cIAP1 Ligand-Linker Conjugates 2 Hydrochloride；化合物 T17890E3 ligase Ligand-Linker Conjugates 37 Hydro (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 2 hydrochloride is a chemical compound that combines an iap ligand, which targets the e3 ubiquitin ligase, with a protac linker. it is utilized in the creation of snipers[1].
Obeticholic Acid；奧貝膽酸INT-747|||6-Ethylchenodeoxycholic acid|||6-ECDCA；奧貝膽酸|||INT-747|||6-Ethylchenod (2024/9/1)
簡(jiǎn)介：obeticholic acid (6-ecdca) is a farnesoid x receptor agonist. the mechanism of action of obeticholic acid is as a farnesoid x receptor agonist.
cIAP1 Ligand-Linker Conjugates 14；化合物 T17889E3 ligase Ligand-Linker Conjugates 36；E3 ligase Ligand-L (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 14 consist of an iap ligand that targets the e3 ubiquitin ligase and a protac linker. these conjugates, known as ciap1 ligand-linker conjugates 14, are used in the development of snipers[1].
cIAP1 Ligand-Linker Conjugates 6 hydrochloride；化合物 T17888E3 ligase Ligand-Linker Conjugates 35 hydro (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 6 hydrochloride is a compound that combines an iap ligand for the e3 ubiquitin ligase and a protac linker. it is utilized for the purpose of designing snipers[1].
cIAP1 Ligand-Linker Conjugates 15；化合物 T17887E3 ligase Ligand-Linker Conjugates 34；E3 ligase Ligand-L (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 15 consists of an iap ligand that targets the e3 ubiquitin ligase, along with a protac linker. this compound, ciap1 ligand-linker conjugates 15, is suitable for the development of snipers[1].
cIAP1 Ligand-Linker Conjugates 15 hydrochloride；化合物 T17886E3 ligase Ligand-Linker Conjugates 34 hydr (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 15 hydrochloride is a chemical compound that combines an iap ligand for the e3 ubiquitin ligase and a protac linker. this compound is useful in the development of snipers[1].
cIAP1 Ligand-Linker Conjugates 11；化合物 T17885E3 ligase Ligand-Linker Conjugates 33；E3 ligase Ligand-L (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 11 is a chemical compound that combines an iap ligand specifically designed for the e3 ubiquitin ligase with a protac linker. this compound, ciap1 ligand-linker conjugates 11, is useful in the development of snipers[1], allowing for the targeted degradation of proteins.
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride；化合物 T17884E3 ligase Ligand-Linker Conjugates 33 Hydr (2024/9/1)
簡(jiǎn)介：ciap1 ligand-linker conjugates 11 hydrochloride is a chemical compound consisting of an iap ligand that targets the e3 ubiquitin ligase, along with a protac linker. it is primarily utilized in the development of snipers, a molecular tool for targeted protein degradation[1].
Pomalidomide-PEG3-C2-NH2；化合物Pomalidomide-PEG3-C2-NH2Cereblon Ligand-Linker Conjugates 5|||E3 ligase (2024/9/1)
簡(jiǎn)介：pomalidomide-peg3-c2-nh2 (cereblon ligand-linker conjugates 5) is a synthesized e3 ligase ligand-linker conjugate incorporating the pomalidomide based cereblon ligand and 3-unit peg linker.
Pomalidomide-PEG3-C2-NH2 (TFA)；化合物 T17882Cereblon Ligand-Linker Conjugates 5 (TFA)|||E3 ligase Ligan (2024/9/1)
簡(jiǎn)介：pomalidomide-peg3-c2-nh2 tfa is a synthesized e3 ligase ligand-linker conjugate that incorporates the pomalidomide based cereblon ligand and 3-unit peg linker used in protac technology.
(S,R,S)-AHPC-C10-NH2；化合物(S,R,S)-AHPC-C10-NH2VH032-C10-NH2；VH032-C10-NH2 (2024/9/1)
簡(jiǎn)介：(s,r,s)-ahpc-c10-nh2 (vh032-c10-nh2) is a synthesized e3 ligase ligand-linker conjugate, comprising the (s,r,s)-ahpc-based vhl ligand and a linker, designed for bet-targeted protac applications.
E3 ligase Ligand 9；化合物 T17880E3 ligase Ligand 9 (2024/9/1)
簡(jiǎn)介：e3 ligase ligand 9 is a compound that serves as a ligand for e3 ubiquitin ligase. it can be linked to the protein ligand through a linker, forming protacs or snipers. these protacs are known to induce the degradation of cancer-promoting proteins through ubiquitination-mediated mechanisms[1].
Tazemetostat；化合物EPZ6438E-7438|||EPZ6438；E-7438|||EPZ6438 (2024/9/1)
簡(jiǎn)介：tazemetostat (epz6438) is a histone methyltransferase ezh2 inhibitor (ic50=11 nm) that is orally active, selective, and sam-competitive. tazemetostat exhibits antitumor activity and may be used for the treatment of epithelioid sarcoma/follicular lymphoma.
英國(guó)雷尼紹M3三坐標(biāo)測(cè)針 (2024/9/1)
簡(jiǎn)介：紅寶石是一種ji為堅(jiān)硬的材料，因此測(cè)球的磨損甚微。它還具有較低密度，使測(cè)尖的質(zhì)量min，從而避免了因設(shè)備運(yùn)行或振動(dòng)而引起測(cè)頭的誤觸發(fā)。
E3 ligase Ligand 8；化合物E3 ligase Ligand 8E3 ligase Ligand 8 (2024/9/1)
簡(jiǎn)介：e3 ligase ligand 8 is a ligand for e3 ubiquitin ligase. the e3 ligase ligand 8 can be linked to protein ligands through linkers to form protacs, which are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
Lenalidomide-C4-NH2 hydrochloride；化合物 T17878Cereblon ligand 1 hydrochloride|||E3 ligase Ligand-Linke (2024/9/1)
簡(jiǎn)介：lenalidomide-c4-nh2 hydrochloride is a cereblon ligand derived from lenalidomide. it serves as a recruiting agent for the crbn protein. the compound, known as protac (compound 24), can be formed by linking lenalidomide-c4-nh2 hydrochloride to the ligand for the protein. it exhibits inhibitory effects with ic50s of 0.98 nm and 13.7 nm against the growth of rs4;11 and molm-13 acute leukemia cell lines, respectively[1].
英國(guó)雷尼紹M3三坐標(biāo)測(cè)針 (2024/9/1)
簡(jiǎn)介：紅寶石是一種ji為堅(jiān)硬的材料，因此測(cè)球的磨損甚微。它還具有較低密度，使測(cè)尖的質(zhì)量min，從而避免了因設(shè)備運(yùn)行或振動(dòng)而引起測(cè)頭的誤觸發(fā)。
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